3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 178516917, compound

HRID 2273244Notes

Reaction equation

HRID 2273244 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([CH:8]2[CH2:21][C:20]3[C:19]4[C:14](=[CH:15][CH:16]=[C:17]([OH:22])[CH:18]=4)[N:13]=[CH:12][C:11]=3[O:10][CH2:9]2)[CH2:4][CH2:3]1.[O:23]=[C:24]1[NH:29][C:28]2[CH:30]=[C:31]([C:34](O)=[O:35])[CH:32]=[CH:33][C:27]=2[S:26][CH2:25]1>>[OH:22][C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[O:10][CH2:9][CH:8]([C@H:5]3[CH2:4][CH2:3][C@H:2]([NH:1][C:34]([C:31]4[CH:32]=[CH:33][C:27]5[S:26][CH2:25][C:24](=[O:23])[NH:29][C:28]=5[CH:30]=4)=[O:35])[CH2:7][CH2:6]3)[CH2:21][C:20]2=1

Participants

3

Reactant 2

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 178511505HCID 178511505, compound

Product 1

HCID 178516917HCID 178516917, compound

Procedure

The titled compound is prepared as a white lyophilizated powder following Scheme 6 and in analogy to Example 15 using 3-(trans-4-amino-cyclohexyl)-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-6-ol and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-9448083621b04ce0813cf8c58118afad
Source dataset
uspto-grants-2015_09
Patent number
US09120822B2

Reaction notes

Loading…