3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 178487823, compound

HRID 2273248Notes

Reaction equation

HRID 2273248 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[N:10]([CH3:17])[CH2:9][CH:8]([C@H:18]3[CH2:23][CH2:22][C@H:21]([NH2:24])[CH2:20][CH2:19]3)[O:7][C:6]2=1.[O:25]=[C:26]1[NH:31][C:30]2[CH:32]=[C:33]([C:36](O)=[O:37])[CH:34]=[CH:35][C:29]=2[S:28][CH2:27]1>>[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[N:10]([CH3:17])[CH2:9][CH:8]([C@H:18]3[CH2:23][CH2:22][C@H:21]([NH:24][C:36]([C:33]4[CH:34]=[CH:35][C:29]5[S:28][CH2:27][C:26](=[O:25])[NH:31][C:30]=5[CH:32]=4)=[O:37])[CH2:20][CH2:19]3)[O:7][C:6]2=1

Participants

3

Reactant 2

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 178487820HCID 178487820, compound

Product 1

HCID 178487823HCID 178487823, compound

Procedure

The titled compound is prepared as an off-white lyophilizated powder following Scheme 7 and in analogy to Example 47 using trans-4-(6-methoxy-1-methyl-2,3-dihydro-1H-4-oxa-1,5,9-triaza-phenanthren-3-yl)-cyclohexylamine and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-a8aa8f52f43341f497d896e019c93e59
Source dataset
uspto-grants-2015_09
Patent number
US09120822B2

Reaction notes

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