3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 178516916, compound

HRID 2273250Notes

Reaction equation

HRID 2273250 reaction equation
[OH:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[CH:12]=O)=[CH:9][CH:8]=[CH:7][CH:6]=2.C(O[C:19](=[O:30])[NH:20][C@H:21]1[CH2:26][CH2:25][C@H:24]([CH2:27][CH:28]=O)[CH2:23][CH2:22]1)(C)(C)C.[O:31]=[C:32]1[NH:37][C:36]2[CH:38]=[C:39](C(O)=O)[CH:40]=[CH:41][C:35]=2[S:34][CH2:33]1>>[O:1]1[C:2]2[CH:3]=[N:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:11]=2[CH2:12][CH:27]([C@H:24]2[CH2:23][CH2:22][C@H:21]([NH:20][C:19]([C:39]3[CH:40]=[CH:41][C:35]4[S:34][CH2:33][C:32](=[O:31])[NH:37][C:36]=4[CH:38]=3)=[O:30])[CH2:26][CH2:25]2)[CH2:28]1

Participants

4

Reactant 3

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 59599757HCID 59599757, compoundHCID 178453924HCID 178453924, compound

Product 1

HCID 178516916HCID 178516916, compound

Procedure

The titled compound is prepared as a white lyophilizated powder following Scheme 6 and in analogy to Example 15 using 3-hydroxy-quinoline-4-carbaldehyde, [trans-4-(2-oxo-ethyl)-cyclohexyl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

Sources & evidence

ORD record
ord-41b6ffc55a824fa484863d6c703b66c7
Source dataset
uspto-grants-2015_09
Patent number
US09120822B2

Reaction notes

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