3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 86671549, compound

HRID 2273259Notes

Reaction equation

HRID 2273259 reaction equation
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[C:9]([C:12]([OH:14])=O)[CH:10]=[CH:11][C:5]=2[S:4][CH2:3]1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]2[C:28](=[CH:29][CH:30]=1)[N:27]=[CH:26][C:25]1[O:24][CH2:23][CH:22]([C:31]3[N:32]=[C:33]([NH2:36])[S:34][CH:35]=3)[CH2:21][C:20]2=1>>[CH3:15][O:16][C:17]1[CH:18]=[C:19]2[C:28](=[CH:29][CH:30]=1)[N:27]=[CH:26][C:25]1[O:24][CH2:23][CH:22]([C:31]3[N:32]=[C:33]([NH:36][C:12]([C:9]4[CH:10]=[CH:11][C:5]5[S:4][CH2:3][C:2](=[O:1])[NH:7][C:6]=5[CH:8]=4)=[O:14])[S:34][CH:35]=3)[CH2:21][C:20]2=1

Participants

3

Reactant 2

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 86671548HCID 86671548, compound

Product 1

HCID 86671549HCID 86671549, compound

Procedure

The titled compound is prepared as a white lyophilizated powder following Scheme 1 and in analogy to Example 1 using 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid and 4-(6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-yl)-thiazol-2-ylamine as starting materials.

Sources & evidence

ORD record
ord-c0b56ba67fd7401fbde9429aa7f3a976
Source dataset
uspto-grants-2015_09
Patent number
US09120822B2

Reaction notes

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