Hydrochloric Acid → HCID 57500354, compound

Participants

Reaction Steps

A solution of 2.17 g (38.7 mmol) of potassium hydroxide in 6 ml of water is added to the suspension of 2.0 g (3.87 mmol) of 6-{[6-(benzyloxy)-1-methoxy-2-methylindolizin-3-yl]carbonyl}-2-phenyl-4H-3,1-benzoxazin-4-one in 15 ml of N-methyl-2-pyrrolidone at ambient temperature. The mixture is brought to reflux for 4 hours. After cooling, the reaction medium is poured into an aqueous solution of hydrochloric acid (0.1 M). The precipitate formed is filtered and washed thoroughly with water and then with diisopropyl ether. 1.15 g (70%) of a yellow powder are obtained after drying under vacuum at 50° C.

Provenance & Evidence