Sodium Bicarbonate → HCID 57500361, compound

Participants

Reaction Steps

The solution of 0.87 g (1.60 mmol) of methyl 2-amino-5-[(1-{[3-(2-tert-butoxy-2-oxoethoxy)benzyl]oxy}-2-methylindolizin-3-yl)carbonyl]benzoate in 3.0 ml of trifluoroacetic acid and 16 ml of dichloromethane at ambient temperature is stirred for 4 hours at ambient temperature. The reaction medium is poured into a saturated aqueous solution of sodium bicarbonate and the mixture is washed with ethyl acetate. The aqueous phase is acidified with a saturated aqueous solution of potassium hydrogen sulphate and then extracted with ethyl acetate. The organic phase is washed with a saturated aqueous solution of sodium chloride, dried over sodium sulphate and concentrated under reduced pressure. 0.69 g (88%) of a green solid is obtained.

Provenance & Evidence