Triethylamine → HCID 57500364, compound

Participants

Reaction Steps

0.95 ml (6.80 mmol) of triethylamine and 1.50 g (3.40 mmol) of BOP are added, at ambient temperature, to 0.61 g (3.40 mmol) of 3-acetoxybenzoic acid in suspension in 20 ml of N,N-dimethylformamide. After 15 minutes, 1.0 g (3.09 mmol) of methyl 2-amino-5-[(1-amino-2-methylindolizin-3-yl)carbonyl]benzoate (described in Patent Application WO2003084956) in 10 ml of N,N-dimethylformamide is added. The reaction medium is stirred for 16 hours under argon and then diluted with ethyl acetate and washed with a saturated aqueous solution of sodium bicarbonate. The organic phase is washed with a saturated aqueous solution of sodium chloride, dried over sodium sulphate and concentrated under reduced pressure. The solid obtained is taken up in acetone and then filtered and dried. 0.86 g (57%) of a greenish yellow powder is obtained.

Provenance & Evidence