Hydrochloric Acid → HCID 57500366, compound

Participants

Reaction Steps

0.46 g (3.30 mmol) of potassium carbonate dissolved in 4 ml of water is added to the suspension of 0.80 g (1.65 mmol) of methyl 5-[(1-{[3-(acetyloxy)benzoyl]-amino}-2-methylindolizin-3-yl)carbonyl]-2-aminobenzoate in 16 ml of methanol. The reaction medium is stirred at ambient temperature for 1 hour, it gradually becomes homogenized. It is diluted with ethyl acetate and acidified with a molar solution of hydrochloric acid. The two phases are separated. The organic phase is washed with a saturated aqueous solution of sodium chloride, dried over sodium sulphate and concentrated under reduced pressure. The solid obtained is taken up in ethyl ether and then filtered and dried. 0.61 g (84%) of a greenish yellow powder is obtained.

Provenance & Evidence