HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 57500367, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Pyridinemethanamine | HCID 19509 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 3-Acetoxybenzoic acid | HCID 238669 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57500367 | HCID 57500367 | — |
Reaction Steps
93 ml (0.66 mol) of triethylamine and 160 g (0.36 mol) of benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP) are added, at ambient temperature under argon, to 65.0 g (0.36 mol) of 3-acetoxybenzoic acid in solution in 600 ml of dichloromethane. After 10 minutes, 32.5 g (0.30 mol) of 2-(aminomethyl)pyridine in solution in 200 ml of dichloromethane are added dropwise at 0° C. The reaction medium is allowed to return to ambient temperature and then stirred for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09120819B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-6cf1311cfaea492c8f79025a92622ba0 |
| Source note | uspto-grants-2015_09 |