Pyridine → HCID 57500372, compound

Participants

Reaction Steps

4.43 ml (43.7 mmol) of pyridine and 8.95 g (21.9 mmol) of tert-butyl[2-(3-{[(2-methylindolizin-1-yl)amino]-carbonyl}phenoxy)ethyl]carbamate are added to the suspension of 9.27 g (24.0 mmol) of benzyl 5-(chlorocarbonyl)-2-[(trifluoroacetyl)amino]benzoate in 180 ml of dichloromethane. The reaction medium that has turned greenish is stirred at ambient temperature for 16 hours. It is concentrated to dryness and the residue is taken up in diisopropyl ether and ethanol. The solid in suspension is filtered, washed with diisopropyl ether and dried. 6.29 g (38%) of a yellow powder are obtained.

Provenance & Evidence