Trifluoroacetic acid → HCID 57500374, compound

Participants

Reaction Steps

16 ml (0.20 mol) of trifluoroacetic acid are added to the suspension of 6.28 g (8.28 mmol) of benzyl 5-({1-[(3-{2-[(tert-butoxycarbonyl)amino]ethoxy}benzoyl)-amino]-2-methylindolizin-3-yl}carbonyl)-2-[(trifluoroacetyl)amino]benzoate in 40 ml of dichloromethane. After stirring at ambient temperature for 30 minutes, the reaction medium is poured into 1 l of a saturated aqueous solution of sodium bicarbonate. The precipitate is filtered, washed thoroughly with water and then with diisopropyl ether and dried, so as to obtain 4.5 g (82%) of a yellow powder.

Provenance & Evidence