HCID 57500378, compound → HCID 57500394, compound

HRID 2273549Notes

Reaction equation

HRID 2273549 reaction equation
[NH2:1][CH2:2][C:3]([NH:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[C:11]([CH:50]=[CH:51][CH:52]=1)[C:12]([NH:14][C:15]1[C:16]([CH3:49])=[C:17]([C:24]([C:26]2[CH:27]=[CH:28][C:29]([NH:42][C:43](=[O:48])[C:44]([F:47])([F:46])[F:45])=[C:30]([CH:41]=2)[C:31]([O:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[O:32])=[O:25])[N:18]2[C:23]=1[CH:22]=[CH:21][CH:20]=[CH:19]2)=[O:13])=[O:4].[CH2:53]([O:60][C:61]([C:63]1[CH:64]=[C:65]([CH:92]=[CH:93][C:94]=1[NH:95][C:96](=[O:101])[C:97]([F:100])([F:99])[F:98])[C:66]([C:68]1[N:76]2[C:71]([CH:72]=[CH:73][CH:74]=[CH:75]2)=[C:70]([NH:77][C:78]([C:80]2[CH:81]=[C:82]([CH:88]=[CH:89][CH:90]=2)[O:83][CH2:84][C:85](O)=[O:86])=[O:79])[C:69]=1[CH3:91])=[O:67])=[O:62])[C:54]1[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1>>[CH2:53]([O:60][C:61]([C:63]1[CH:64]=[C:65]([CH:92]=[CH:93][C:94]=1[NH:95][C:96](=[O:101])[C:97]([F:100])([F:99])[F:98])[C:66]([C:68]1[N:76]2[C:71]([CH:72]=[CH:73][CH:74]=[CH:75]2)=[C:70]([NH:77][C:78]([C:80]2[CH:81]=[C:82]([CH:88]=[CH:89][CH:90]=2)[O:83][CH2:84][C:85]([NH:1][CH2:2][C:3]([NH:5][CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([CH:50]=[CH:51][CH:52]=2)[C:12]([NH:14][C:15]2[C:16]([CH3:49])=[C:17]([C:24]([C:26]3[CH:27]=[CH:28][C:29]([NH:42][C:43](=[O:48])[C:44]([F:45])([F:46])[F:47])=[C:30]([CH:41]=3)[C:31]([O:33][CH2:34][C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)=[O:32])=[O:25])[N:18]3[C:23]=2[CH:22]=[CH:21][CH:20]=[CH:19]3)=[O:13])=[O:4])=[O:86])=[O:79])[C:69]=1[CH3:91])=[O:67])=[O:62])[C:54]1[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=1

Participants

3

Reactant 2

HCID 57500378HCID 57500378, compoundHCID 57500393HCID 57500393, compound

Product 1

HCID 57500394HCID 57500394, compound

Procedure

By following the process described in stage G of Example 42, the coupling of the amine obtained in stage A above with (3-{[(3-{3-[(benzyloxy)carbonyl]-4-[(trifluoroacetyl)amino]benzoyl}-2-methylindolizin-1-yl)amino]carbonyl}phenoxy)acetic acid (described in stage D of Example 44) is carried out.

Sources & evidence

ORD record
ord-3b8a7f62eb7a4fbd92f58e5c9a3ebb24
Source dataset
uspto-grants-2015_09
Patent number
US09120819B2

Reaction notes

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