Carbonate Ion → Mepivacaine

HRID 2273579Notes

Reaction equation

HRID 2273579 reaction equation
[CH3:1][C:2]1[C:7]([NH:8][C:9]([CH:11]2[N:16]([CH3:17])[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:10])=[C:6]([CH3:18])[CH:5]=[CH:4][CH:3]=1.Cl.C(=O)([O-])[O-]>>[CH3:1][C:2]1[C:7]([NH:8][C:9]([CH:11]2[N:16]([CH3:17])[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:10])=[C:6]([CH3:18])[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 19660Carbonate IonHCID 66070Mepivacaine Hydrochloride

Product 1

HCID 4062Mepivacaine

Procedure

In a first vial, Mepivacaine-HCl (1.8, 3.7 or 7.4 mg), SG-PEG (50 mg) and PEG-SH (50 mg) were dissolved in 250 μL of pH 2.2 buffer. This solution was combined with an equal volume of carbonate buffer (pH 9.7) through a spray kit. Mepivacaine precipitated within the gel upon mixing All Mepivacaine-loaded gels swelled 1.5-2 times their original volume. In vitro release studies showed a slight burst of mepivacaine from the gel. At 9 days, 60% of the drug was released.

Workup

  1. customMepivacaine precipitated within the gel
  2. additionupon mixing All Mepivacaine-loaded gels

Sources & evidence

ORD record
ord-8bb9c67c504a40df94bf781825ae0a06
Source dataset
uspto-grants-2015_09
Patent number
US09125814B2

Reaction notes

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