HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonate Ion → Ropivacaine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonate Ion | HCID 19660 | — |
| Reactant | Ropivacaine Hydrochloride | HCID 175804 | — |
| Reactant | (2,5-Dioxopyrrolidin-1-yl) carbonate | HCID 22239412 | — |
| Product | Ropivacaine | HCID 175805 | — |
Reaction Steps
In a first vial, Ropivacaine-HCl (8.6 mg), 4-armPEG succinimidyl carbonate (60 mg) and 4-armPEG-SH (60 mg) were dissolved in 250 μL of pH 2.2 buffer. This solution was combined with an equal volume of carbonate buffer (pH 9.7) through a spray kit. Ropivacaine precipitates within the gel upon mixing. The Ropivacaine-loaded TC gel swelled 2-2.5 times its original volume.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09125814B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-5ac4fa8c655d4a9b834393db8da65918 |
| Source note | uspto-grants-2015_09 |