Theophylline → Aminophylline tannic acid

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Aminophylline, a bronchodilator drug combination that contains the alkaloid theophylline, and ethylenediamine in 2:1 ratio, was selected as a model alkaloid for use in the preparation of the present compositions exhibiting diversion- and/or abuse-resistant properties. 100 ml of 2.4% wt. aminophylline aqueous solution was mixed with predetermined volumes of 13% wt. tannic acid aqueous solution and 20% wt. PEG aqueous solution to yield an aminophylline/tannic acid/PEG weight ratio of about 1.0:1.0:7.0.

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