反应详情

Tin(II) chloride (1.69 g, 8.90 mmol) is added to a solution of 4-bromo-N-isopropyl-2-nitroaniline (770 mg, 2.97 mmol) in ethanol. The mixture may be heated to reflux for an appropriate time (such as 4 hr) and cooled. 4 N sodium hydroxide is added to the solution which then may be filtered. The filtrate is extracted with ethyl acetate. The combined organic layer may be washed with brine and concentrated. The residue may be purified by any appropriate method including Biotage column chromatography to give 4-bromo-N-1-isopropylbenzene-1,2-diamine (513 mg).

1. temperatureThe mixture may be heated
2. temperatureto reflux for an appropriate time (such as 4 hr)
3. temperaturecooled
4. filtrationmay be filtered
5. extractionThe filtrate is extracted with ethyl acetate
6. washThe combined organic layer may be washed with brine
7. concentrationconcentrated
8. customThe residue may be purified by any appropriate method