HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,3-Dichlorophenyl)piperazine → Aripiprazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,3-Dichlorophenyl)piperazine | HCID 851833 | — |
| Reactant | 7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone | HCID 10542064 | — |
| Product | Aripiprazole | HCID 60795 | — |
Reaction Steps
Conventional anhydrous aripiprazole crystals are prepared by well-known methods, as described in Example 1 of Japanese Unexamined Patent Publication No. 191256/1990. 7-(4-bromobutoxy)-3,4-dihydrocarbostyril, is reacted with 1-(2,3-dichlorophenyl)piperazine and the thus obtained crude aripiprazole crystals are re-crystallized from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09125939B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-972bde89ca7c4b23a245358e7f63044f |
| Source note | uspto-grants-2015_09 |