HCID 118348002, compound → HCID 178461043, compound

Participants

Reaction Steps

The title compound is prepared from 5 (above) and (S)-tert-butyl 2-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (Syngene) using the Suzuki-Miyaura cross-coupling procedure outlined above for the preparation of (7). Yield: 156.9 mg (66%). HPLC: tR 1.88 min (method 1); tR 2.28 min, 96.6% purity (method 2). LC-MS m/z calcd for C39H48N6O5S ([M]+), 712. found, 713 ([M+H]+). 1H NMR (CDCl3): δ 1.06 (t, J=7.0 Hz, 3H), 1.51 (s, 9H), 1.86 (m, 2H), 1.98 (m, 1H), 2.17 (m, 2H), 2.53 (m, 4H), 2.88 (m, 2H), 3.07 (m, 1H), 3.29 (m, 4H), 3.43 (m, 2H), 3.53 (s, 2H), 4.98 (m, 1H), 7.28 (br, 1H), 7.32 (m, 2H), 7.56 (br, 1H), 7.63 (m, 2H), 7.73 (m, 2H), 7.87 (m, 2H), 7.93 (m, 2H).

Provenance & Evidence