N-[2-[N-ethyl-N-[2-[[(2-fluoropyridin-4-yl)carbonyl]amino]ethyl]amino]ethyl]-6-iodoquinoxaline-2-carboxamide → N-[2-[N-ethyl-N-[2-[[(2-fluoropyridin-4-yl)carbonyl]amino]ethyl]amino]ethyl]-6-iodoquinoxaline-2-carboxamide dihydrochloride salt

Participants

Reaction Steps

This compound was prepared, starting from compound 39 (158 mg, 0.30 mmol), according to the procedure developed for compound 11. Reaction time at room temperature: 12 h to give compound 40 (152 mg, 0.25 mmol) as a very hygroscopic beige solid. Yield 84%; mp 157-159° C.; IR (KBr) ν 1163, 1228, 1308, 1402, 1475, 1535, 1690, 2400-2700, 2800-3100, 3200-3500 cm−1; 1H NMR (200 MHz, DMSO-d6) δ 1.28 (t, 3H, J=6.7 Hz), 3.37 (m, 6H, J=7.1 Hz), 3.77 (m, 4H), 7.57 (s, 1H), 7.75 (d, 1H, J=5.0 Hz), 7.86 (d, 1H, J=8.8 Hz), 8.21 (dd, 1H, J=1.7, 8.8 Hz), 8.32 (d, 1H, J=5.0 Hz), 8.59 (d, 1H, J=1.7 Hz), 9.39 (s, 1H), 9.42 (m, 2H), 10.58 (se, 1H); ESI-MS m/z 537.0 [M+H]+; Anal. Calcd for C21H22O2IN6F, 2HCl: C, 41.40; H, 3.97; N, 13.79. Found: C, 42.67; H, 4.39; N, 13.66.

Provenance & Evidence