2-Fluoro-4-(3-hydroxypropyl)pyridine → HCID 52951814, compound

Participants

Reaction Steps

This compound was prepared, starting from compound 48 (5.00 g, 32.2 mmol), according to the procedure developed for compound 43. Reaction time at 0° C.: 30 min; the purification was performed using column chromatography (SiO2, AcOEt/pentane, 8/2, v/v) to give compound 49 (4.82 g, 20.7 mmol) as a yellow oil. Yield 69%; Rf (SiO2, AcOEt/pentane, 8/2, v/v) 0.58; IR (CCl4) ν 1179, 1351, 1371, 1413, 1613 cm−1; 1H NMR (200 MHz, CDCl3) δ 2.12 (m, 2H), 2.83 (t, 2H, J=7.3 Hz), 3.05 (s, 3H), 4.28 (t, 2H, J=6.1 Hz), 6.80 (s, 1H), 7.07 (m, 1H), 8.15 (d, 1H, J=5.1 Hz).

Provenance & Evidence