N-[2-[N-ethyl-N-[2-(2-fluoropyridin-3-yloxy)ethyl]amino]ethyl]-6-iodonaphthalene-2-carboxamide → N-[2-[N-ethyl-N-[2-(2-fluoropyridin-3-yloxy)ethyl]amino]ethyl]-6-iodonaphthalene-2-carboxamide hydrochloride salt

Participants

Reaction Steps

This compound was prepared, starting from compound 70 (150 mg, 0.30 mmol), according to the procedure developed for compound 11. Reaction time at room temperature: 12 h to give compound 71 (127 mg, 0.23 mmol) as a very hygroscopic beige solid. Yield 77%; mp 157-159° C.; IR (KBr) ν 1124, 1186, 1241, 1312, 1457, 1545, 1653, 2612, 3221 cm−1; 1H NMR (200 MHz, DMSO-d) δ 1.32 (t, 3H, J=7.0 Hz), 3.44 (m, 4H), 3.74 (m, 4H), 4.58 (t, 2H, J=4.5 Hz), 7.29 (ddd, 1H, 5JH-F=0.6 Hz, J=5.1, 7.7 Hz), 7.82 (m, 6H), 8.47 (s, 1H), 8.52 (s, 1H), 9.16 (te, 1H, J=4.9 Hz), 10.82 (se, 1H).

Provenance & Evidence