Ammonia → Glycinate

HRID 2273832Notes

Reaction equation

HRID 2273832 reaction equation
[ClH:1].[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].N>CCOCC>[NH2:7][CH2:6][C:5]([O-:8])=[O:4].[ClH:1].[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 2723640Glycine ethyl ester, hydrochloride2×

Product 2

HCID 26066GlycinateHCID 2723640Glycine ethyl ester, hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Add 139.6 g of glycine ethyl ester hydrochloride into 1100 ml of anhydrous ether, ice cold the solution to −6° C. by passing 27.2 g of ammonia gas, so that the glycine ethyl ester hydrochloride is ionized to form glycinate, wherein the proportion of glycine ethyl ester hydrochloride:anhydrous ether:ammonia gas is 1 mol: 1100 ml:1.6 mol.

Sources & evidence

ORD record
ord-a9dd58dbda6d4ea3885d595030ad2554
Source dataset
uspto-grants-2015_09
Patent number
US09126928B2

Reaction notes

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