Sodium Hydroxide → HCID 68357550, compound

HRID 2274010Notes

Reaction equation

HRID 2274010 reaction equation
[Cl:1][C:2]1[C:3]([C:11]2(Cl)[CH2:13][CH2:12]2)=[N:4][N:5]([CH3:10])[C:6]=1[C:7]([OH:9])=[O:8].[F:15]C1(C2C=C(C(OCC)=O)N(C)N=2)CC1.[OH-].[Na+]>CO>[Cl:1][C:2]1[C:3]([C:11]2([F:15])[CH2:13][CH2:12]2)=[N:4][N:5]([CH3:10])[C:6]=1[C:7]([OH:9])=[O:8]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 68326403HCID 68326403, compoundHCID 68326506HCID 68326506, compound

Product 1

HCID 68357550HCID 68357550, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The preparation was carried out analogously to the preparation of 4-chloro-3-(1-chlorocyclopropyl)-1-methyl-1H-pyrazole-5-carboxylic acid using ethyl 3-(1-fluorocyclopropyl)-1-methyl-1H-pyrazole-5-carboxylate and 5.0 eq of sodium hydroxide in methanol.

Sources & evidence

ORD record
ord-ff6ef33d88654643b42ed22fe2be4415
Source dataset
uspto-grants-2015_09
Patent number
US09126945B2

Reaction notes

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