反应详情

A solution of tetrahydropyran-4-yl acetic acid (Combi-Blocks, Inc., 0.18 g, 1.2 mmol) in thionyl chloride (7 mL, 96 mmol, excess) was refluxed for 1 h then was cooled to ambient temperature and concentrated under reduced pressure. The residue was azeotroped twice with 10 mL of benzene to remove any remaining thionyl chloride. The resulting acid chloride was used without further purification.

1. concentrationconcentrated under reduced pressure
2. customThe residue was azeotroped twice with 10 mL of benzene
3. customto remove any remaining thionyl chloride
4. customThe resulting acid chloride was used without further purification