HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (R)-Solketal | HCID 736056 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl methanesulfonate | HCID 24903512 | — |
Reaction Steps
The (R)-(−)-2,2-dimethyl-1,3-dioxolane-4-methanol (Aldrich, 0.38 mL, 3.1 mmol), triethylamine (0.85 mL, 6.1 mmol), and methanesulfonyl chloride (0.31 mL, 4.1 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560481B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-e158575da21c4b91b9a0a6b159c58000 |
| Source note | uspto-grants-2009_07 |