Indole → HCID 44626730, compound

Participants

Reaction Steps

A mixture of 2,2,3,3-tetrafluoro-1-(methyl)-cyclobutanecarbonyl chloride (ABCR, 1.0 g, 4.9 mmol), indole (0.57 g, 4.9 mmol), ethylmagnesium bromide (1.0 M solution in THF, 5.4 ml, 5.4 mmol) and zinc chloride (1.0 M solution in Et2O, 5.4 mL, 5.4 mmol) in 50 mL of dichloromethane was processed as described in Example 1B to provide the title compound (0.40 g, 1.4 mmol, 29% yield). MS (DCI/NH3) m/z 286 (M+H)+.

Provenance & Evidence