Sodium Carbonate → HCID 86711467, compound

Participants

Reaction Conditions

Reaction Steps

Into a microwave vial was added 1-(3-bromo-5-chloro-2-methoxy-4-methylphenyl)ethanone (0.040 g, 0.14 mmol), [5-(methylsulfonyl)pyridin-3-yl]boronic acid (0.035 g, 0.17 mmol), 1.0 M sodium carbonate (0.35 mL, 0.35 mmol), 1,4-dioxane (0.87 mL) and tetrakis(triphenylphosphine)palladium(0) (0.010 g, 0.0086 mmol). The mixture was bubbled with N2 for 5 min, then heated at 100° C. overnight. The cooled reaction mixture was purified on silica gel to give the desired product (0.035 g, 71%). LCMS calculated for C16H17ClNO4S (M+H)+: m/z=354.1. found: 354.0.

Provenance & Evidence