Tetrahydrofuran → HCID 72332051, compound

Participants

Reaction Steps

Under the atmosphere of argon, 25.0 g of 9-(2-formylphenyl)phenanthrene, 33.4 g of methoxymethyltriphenylphosphonium chloride and 300 mL of THF were placed, and 11.9 g of potassium t-buthoxide was added at room temperature during stirring. After stirring at room temperature for 2 hours, 200 mL of water was added. The reaction solution was extracted with diethyl ether, and an aqueous phase was removed. An organic phase was washed with water and saturated saline, and dried with magnesium sulfate. After filtering off magnesium sulfate, the organic phase was concentrated. The residues were purified by silica gel column chromatography, whereby 24.0 g (yield 87%) of 9-[2-(2-methoxyvinyl)phenyl]phenanthrene as an intended product was obtained.

Provenance & Evidence