HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2274142Generated: October 29, 2026
Phosphorus oxychloride → 7-Bromo-4-chloroquinazoline
https://huagongshe.com/reaction/2274142
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 7-Bromo-3,4-dihydroquinazolin-4-one | HCID 135555612 | — |
| Product | 7-Bromo-4-chloroquinazoline | HCID 16780855 | — |
Reaction Steps
20.4 ml (0.12 mol) of N-ethyldiisopropylamine were slowly added to a suspension of 55.0 g (0.24 mol) of 7-bromo-3H-quinazolin-4-one in 300 ml of phosphorus oxytrichloride. The reaction mixture was stirred at 115° C. for 3 h and subsequently allowed to come to room temperature. Conventional work-up gave 48.0 g of 7-bromo-4-chloroquinazoline; HPLC/MS (M+H)+=244 as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09126952B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-88fedd410b7a4977b1c1eba90365a769 |
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| Source note | uspto-grants-2015_09 |
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