HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2274146Generated: October 31, 2026
Phosphorus oxychloride → 4-(4-Chloroquinazolin-7-yl)morpholine
https://huagongshe.com/reaction/2274146
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 7-(Morpholin-4-yl)quinazolin-4(3H)-one | HCID 135742360 | — |
| Product | 4-(4-Chloroquinazolin-7-yl)morpholine | HCID 53468617 | — |
Reaction Steps
1.3 ml (7.57 mmol) of N-ethyldiisopropylamine were slowly added dropwise to a suspension of 3.5 g (15.11 mmol) of 7-morpholin-4-yl-3H-quinazolin-4-one in 20 ml of phosphoryl chloride. The reaction mixture was subsequently stirred at 115° C. for 2 h. Conventional work-up gave 3.75 g of 4-chloro-7-morpholin-4-ylquinazoline; HPLC/MS (M+H)+=250 as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09126952B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-e18405b53bc74e1bac8378c6ed66d3e3 |
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| Source note | uspto-grants-2015_09 |
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