HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylethyl 4-(4-morpholinyl)-2-nitrobenzoate → HCID 53468423, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylethyl 4-(4-morpholinyl)-2-nitrobenzoate | HCID 57703881 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 53468423 | HCID 53468423 | 100% |
Reaction Steps
127 g (0.412 mol) of tert-butyl 4-morpholin-4-yl-2-nitrobenzoate (WO 2007/06837 A1) were dissolved in 1000 ml of tetrahydrofuran, 12.7 g of palladium/carbon (5%, water-moist) were added, and the mixture was stirred over hydrogen at room temperature for 5 h. Conventional work-up gave 4.5 g (Y=100%) of tert-butyl 2-amino-4-morpholin-4-ylbenzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126952B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-a337991b95c1490da71936ae088e080f |
| Source note | uspto-grants-2015_09 |