HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamidine acetate → 7-Fluoroquinazolin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamidine acetate | HCID 160693 | — |
| Reactant | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-Fluoroquinazolin-4(3H)-one | HCID 135398496 | 82.4% |
Reaction Steps
25.0 g (0.156 mol) of 2-amino-4-fluorobenzoic acid and 33.0 g (0.317 mol) of formamidine acetate were suspended in 250 ml of ethanol. The reaction mixture was subsequently stirred under reflux for 16 h. Conventional work-up gave 21.1 g (Y=82%) of 7-fluoro-3H-quinazolin-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126952B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-8abcc68230144ae3a55a4e690b8b88ed |
| Source note | uspto-grants-2015_09 |