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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2274151Generated: October 29, 2026

Formamidine acetate → 6,7-Difluoroquinazolin-4(3H)-one

https://huagongshe.com/reaction/2274151

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormamidine acetateHCID 160693—
Reactant2-Amino-4,5-difluorobenzoic acidHCID 735965—
SolventEthanolHCID 702—
Product6,7-Difluoroquinazolin-4(3H)-oneHCID 13547130886%

Reaction Steps

38.0 g (0.213 mol) of 2-amino-4,5-difluorobenzoic acid and 44.0 g (0.423 mol) of formamidine acetate were suspended in 300 ml of ethanol. The reaction mixture was subsequently stirred under reflux for 16 h. Conventional work-up gave 33.37 g (Y=84%) of 6,7-difluoro-3H-quinazolin-4-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09126952B2
Source datasetuspto-grants-2015_09
ORD IDord-74d48643b9344fe0a368098e217cb823
Source noteuspto-grants-2015_09