HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 4-Chloro-6-fluoro-7-morpholin-4-ylquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one | HCID 136000244 | — |
| Product | 4-Chloro-6-fluoro-7-morpholin-4-ylquinazoline | HCID 77230932 | 123.3% |
Reaction Steps
5.0 g (0.02 mol) of 6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one were suspended in 37.0 ml (0.04 mol) of phosphoryl chloride at room temperature, 3.4 ml (0.02 mol) of N-ethyldiisopropylamine were subsequently added, and the mixture was heated under reflux for 2 h. Conventional work-up gave 6.6 g of 4-chloro-6-fluoro-7-morpholin-4-ylquinazoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126952B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-a041d9deafcc4cb6882fded8174b136e |
| Source note | uspto-grants-2015_09 |