HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 64158347, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | 1-Piperidinecarboxylic acid, 3-(hydroxy-3-thienylmethyl)-, 1,1-dimethylethyl ester | HCID 68242724 | — |
| Product | HCID 64158347 | HCID 64158347 | 67.3% |
Reaction Steps
1.0 g (3.36 mmol) of tert-butyl 3-(hydroxythiophen-3-ylmethyl)piperidine-1-carboxylate as diastereomer mixture were stirred with 15 ml of trifluoroacetic acid at 0° C. After 15 min, 0.80 ml (5.04 mmol) of triethylsilane were added dropwise, the cold bath was removed, and the mixture was stirred at room temperature for 18 h. Conventional work-up gave 0.41 g of 3-thiophen-3-ylmethylpiperidine; HPLC/MS (M+H)+=182 as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126952B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-5cef6b29ee3645888a4135a320cbdf92 |
| Source note | uspto-grants-2015_09 |