HuagongsheHuagongshe Chemistry Print Report · For research reference only
methyl 1H-indole-5-carboxylate → HCID 24823930, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | methyl 1H-indole-5-carboxylate | HCID 2737635 | — |
| Reactant | 2,2,3,3-Tetramethylcyclopropane-1-carbonyl chloride | HCID 11041002 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 24823930 | HCID 24823930 | 66% |
Reaction Steps
Methyl-indole-5-carboxylate (Lancaster, 3.0 g, 17 mmol), ethylmagnesium bromide (1.0 M solution in THF, 21 mL, 21 mmol), zinc chloride (1.0 M solution in Et2O, 21 mL, 21 mmol) and the product of Example 1A (26 mmol) in 50 mL of dichloromethane were processed as described in Example 1B to provide the title compound (3.4 g, 11 mmol, 66% yield). MS (DCI/NH3) m/z 300 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560481B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-c3efe622d3d441ee829343fc98d2b14a |
| Source note | uspto-grants-2009_07 |