Ammonia → HCID 67401650, compound

HRID 2274161Notes

Reaction equation

HRID 2274161 reaction equation
Cl[C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][C:6]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[CH:7][CH:8]=2)[N:3]=1.[NH3:19].O1[CH2:25][CH2:24]OCC1>>[N:13]1([C:6]2[CH:5]=[C:4]3[C:9]([C:10]([N:3]4[CH2:25][CH2:24][CH2:6][CH2:5][CH2:4]4)=[N:11][C:2]([NH2:19])=[N:3]3)=[CH:8][CH:7]=2)[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 312751,4-DioxaneHCID 13499313HCID 13499313, compound

Product 1

HCID 67401650HCID 67401650, compound

Procedure

0.166 g (0.50 mmol) of 2,4-dichloro-7-morpholin-4-ylquinazoline and 1.0 ml of ammonia solution (32%) in 2.0 ml of dioxane were heated in a cem microwave at 130° C. (80 watts) for 150 min. Conventional work-up gave 0.04 g of 7-morpholin-4-yl-4-piperidin-1-ylquinazolin-2-ylamine (No. 57).

Sources & evidence

ORD record
ord-69d8d2a5c2704b76b14401b3464a8ed6
Source dataset
uspto-grants-2015_09
Patent number
US09126952B2

Reaction notes

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