HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-nitrophenol → N-(3-((5-fluoro-2-((2-hydroxy-4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-nitrophenol | HCID 9937 | — |
| Reactant | N-(3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide | HCID 86724340 | — |
| Product | N-(3-((5-fluoro-2-((2-hydroxy-4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide | HCID 86724341 | — |
Reaction Steps
The synthesis of N-(3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide was achieved as described above for N-(3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide (I-13) in Example 7 using 5-fluoro-2-nitrophenol in place of 2-fluoro-5-nitrophenol in the first step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126950B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-fb0001da286d463b8e9f8ec7b85ea1de |
| Source note | uspto-grants-2015_09 |