5,6-Bis(phenylmethoxy)-1H-indole → (5,6-Bis-benzyloxy-1H-indol-3-yl)-(2,2,3,3-tetramethyl-cyclopropyl)-methanone

関与物質

役割	名称	HCID	仕込み量
反応物	5,6-Bis(phenylmethoxy)-1H-indole	HCID 20920	—
反応物	2,2,3,3-Tetramethylcyclopropane-1-carbonyl chloride	HCID 11041002	—
反応物	HCID 178418443	HCID 178418443	—
触媒	Zincchloride	HCID 3007855	—
溶媒	Dichloromethane	HCID 6344	—
生成物	(5,6-Bis-benzyloxy-1H-indol-3-yl)-(2,2,3,3-tetramethyl-cyclopropyl)-methanone	HCID 67269830	55%

反応手順

The 5,6-dibenzyloxyindole (Sigma, 0.60 g, 1.8 mmol), ethylmagnesium bromide (1.0 M solution in THF, 2.2 mL, 2.2 mmol), zinc chloride (1.0 M solution in Et2O, 2.2 mL, 2.2 mmol) and the product of Example 1A (2.7 mmol) in 20 mL of dichloromethane were processed as described in Example 1B to provide the title compound (0.45 g, 0.99 mmol, 55% yield). MS (DCI/NH3) m/z 454 (M+H)+.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07560481B2
出典データセット	uspto-grants-2009_07
ORD ID	ord-4ad9650b0f224fbe8fc495790ce41221
出典メモ	uspto-grants-2009_07