反应详情

tert-Butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate (800 mg, 2.37 mmoL) and 4-(2-methoxyethoxy)aniline (576 mg, 2.84 mmoL) were suspended in tert-amyl alcohol (14 mL) and acetic acid (5 drops). Heated to reflux for 4 h. After cooling, solvent was removed via rotary evaporation. The dark oil was partitioned between water/brine and THF (10 mL each), agitated, and separated layers and dried organic phase over sodium sulfate. The solvent was removed via rotary evaporation to afford a purple solid, 0.55 g. LC/MS (RT=2.997/(M+1)) 470.2. Additional 150 mg of product minus the (BOC) protecting group crystallized from the aqueous layer

1. temperatureHeated
2. temperatureto reflux for 4 h
3. temperatureAfter cooling
4. customsolvent was removed via rotary evaporation
5. customThe dark oil was partitioned between water/brine and THF (10 mL each)
6. customseparated layers and dried organic phase over sodium sulfate
7. customThe solvent was removed via rotary evaporation
8. customto afford a purple solid, 0.55 g
9. customLC/MS (RT=2.997/(M+1)) 470.2
10. customcrystallized from the aqueous layer