HCID 71152541, compound → HCID 86727207, compound

Participants

Reaction Steps

A solution of compound 2 (1.4 g, 3.6 mmol) in DCM (25 mL) was treated with DMP (3.1 g, 7.3 mmol) for 3 h at room temperature. The reaction mixture was quenched with saturated aqueous Na2S2O3 (10 mL) and extracted with DCM (4×20 mL). The combined organic layer was washed with saturated aqueous NaHCO3 (20 mL) and brine (10 mL), dried over anhydrous MgSO4, and concentrated in vacuo to give the crude aldehyde 3 (1.4 g, yellow oil), which was used in the next step without further purification. (ES, m/z): [M+H]+ 382.0; 1H NMR (300 MHz, CDCl3), δ: 9.74 (s, 1H), 7.28-7.46 (m, 10H), 4.54-4.85 (m, 5H), 3.85-3.90 (m, 1H), 3.69-3.74 (m, 1H), 3.60-3.65 (m, 1H), 2.94-2.96 (m, 1H), 2.19-2.27 (m, 1H), 1.94-2.00 (m, 1H).

Provenance & Evidence