Benzophenone → HCID 118324209, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 26 (8 mg, 0.028 mmol) and benzophenone (10.2 mg, 0.056 mmol) in a mixture of toluene (1 mL) and DME (1 mL) was added potassium tert-butoxide (18 mg, 0.16 mmol) at room temperature. The resulting reaction mixture was heated at 85° C. for 8 hours and then the solvent was evaporated under reduced pressure to obtain the crude reaction mixture, which was purified by column chromatography on silica gel using [CH2Cl2/MeOH (95:5)→CH2Cl2/MeOH (90:10)] as eluent to provide 4 (3.5 mg, 0.012 mmol, 44%) as a white solid along with unreacted starting material 26 (4 mg, 0.014 mmol, 53%). The physical and spectral properties of 4 were matched with those given in the literature.7

Provenance & Evidence