反应详情

200 mg of 4-fluoro-2-nitro-5-(3-piperidin-1-ylpropoxy)-phenylamine in solution in 15 mL of methanol are hydrogenated under 1 bar of hydrogen pressure in the presence of 20 mg of palladium-on-charcoal at 25° C. for 10 hours. The reaction crude is filtered through celite and the filtrate is concentrated under vacuum in a rotary evaporator. 180 mg of 4-fluoro-5-(3-piperidin-1-ylpropoxy)benzene-1,2-diamine are obtained in the form of a black oil. The product is used without any other purification.

1. customThe reaction crude
2. filtrationis filtered through celite
3. concentrationthe filtrate is concentrated under vacuum in a rotary evaporator