Trifluoroacetic acid → HCID 178483561, compound

Participants

Reaction Conditions

Reaction Steps

0.5 mL of trifluoroacetic acid is added to a solution of 28 mg of piperidine-1-carboxylic acid [3-[6-(3-dimethylaminopropoxy)-5-fluoro-1H-benzimidazol-2-yl]-1-(tetrahydropyran-2-yl)-1H-pyrazol-4-yl]amide in solution in 1.5 mL of dichloromethane. The reaction medium is stirred at 22° C. for 16 hours. The reaction medium is concentrated under reduced pressure in a rotary evaporator, taken up several times with isopropyl ether and concentrated under reduced pressure in a rotary evaporator each time. 40 mg of N-{3-[6-(3-dimethylaminopropoxy)-5-fluoro-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}piperidine-1-carboxamide are obtained in the form of trifluoroacetic acid salt. 1H NMR (300 MHz, DMSO-d6, δ in ppm): 1.47 to 1.72 (m, 6H); 2.19 (m, 2H); 2.84 (s, 6H); 3.27 (m, 2H); 3.42 (m, 4H); 4.22 (t, J=6.0 Hz, 2H); 7.40 (d, J=7.5 Hz, 1H); 7.65 (d, J=10.0 Hz, 1H); 8.00 (s, 1H).

Provenance & Evidence