HCID 178418361, compound → HCID 178483735, compound

Participants

Reaction Steps

350 mg of N1-{6-fluoro-2-[4-nitro-1-(tetrahydropyran-2-yl)-1H-pyrazol-3-yl]-3H-benzimidazol-5-yl}-N2,N2-dimethylethane-1,2-diamine in 15 mL of methanol and 40 mg of palladium-on-charcoal are hydrogenated under 1 bar of hydrogen pressure at 22° C. for 16 hours. The reaction medium is filtered through celite and the filtrate is concentrated under reduced pressure in a rotary evaporator. 300 mg of N1-{2-[4-amino-1-(tetrahydropyran-2-yl)-1H-pyrazol-3-yl]-6-fluoro-3H-benzimidazol-5-yl}-N2,N2-dimethylethane-1,2-diamine are obtained. The compound is used as it is for the subsequent stage.

Provenance & Evidence