2-(Pyridin-2-yl)but-3-yn-2-ol → HCID 71001843, compound

HRID 2274456Notes

Reaction equation

HRID 2274456 reaction equation
[NH2:1][C:2]1[N:3]([CH2:27][CH3:28])[C:4]2[C:9]([C:10](=[O:25])[C:11]=1[C:12]1[N:13](COCC[Si](C)(C)C)[CH:14]=[CH:15][N:16]=1)=[CH:8][CH:7]=[C:6](Cl)[N:5]=2.[N:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[C:35]([OH:39])([C:37]#[CH:38])[CH3:36]>>[NH2:1][C:2]1[N:3]([CH2:27][CH3:28])[C:4]2[C:9]([C:10](=[O:25])[C:11]=1[C:12]1[NH:16][CH:15]=[CH:14][N:13]=1)=[CH:8][CH:7]=[C:6]([C:38]#[C:37][C:35]([OH:39])([C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][N:29]=1)[CH3:36])[N:5]=2

Participants

3

Reactant 2

HCID 167625022-(Pyridin-2-yl)but-3-yn-2-olHCID 86714575HCID 86714575, compound

Product 1

HCID 71001843HCID 71001843, compound

Procedure

Using the intermediate described under 1.6 (2-amino-7-chloro-1-ethyl-3-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-1H-[1,8]naphthyridin-4-one) and coupling it to (±)-2-pyridin-2-yl-but-3-yn-2-ol following the detailed procedure outlined for example 1 in an analogous manner the title compound was accessed.

Sources & evidence

ORD record
ord-66fc480750b34a99b7cffdd56ed74f33
Source dataset
uspto-grants-2015_09
Patent number
US09126972B2

Reaction notes

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