Ethylamine → HCID 71001823, compound

HRID 2274460Notes

Reaction equation

HRID 2274460 reaction equation
F[C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:12]([NH2:14])[CH3:13]>>[CH2:12]([NH:14][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])[CH3:13]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 27745162-Fluoro-4-iodobenzoic acid

Product 1

HCID 71001823HCID 71001823, compound

Conditions

Temperature
125 °C

Procedure

3.5 g (13.16 mmol) of 2-fluoro-4-iodobenzoic acid were mixed to a 16.11 ml solution of ethylamine (70% in water) in a sealed tube. The reaction vessel was heated and stirred at 125° C. during 24 hours. Nitrogen was bubbled through the reaction mixture to eliminate the excess of ethylamine. The reaction mixture was than poured into an iced water solution and the mixture acidified to pH=3-4 with acetic acid. The resulting white solid was then filtered off, washed with water and dried to give 2.2 g (7.55 mmol).

Workup

  1. temperatureThe reaction vessel was heated
  2. customNitrogen was bubbled through the reaction mixture
  3. additionthan poured into an iced water solution
  4. filtrationThe resulting white solid was then filtered off
  5. washwashed with water
  6. customdried
  7. customto give 2.2 g (7.55 mmol)

Sources & evidence

ORD record
ord-de6674471add450cbca7c58f0610b515
Source dataset
uspto-grants-2015_09
Patent number
US09126972B2

Reaction notes

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