Hydrochloric Acid → 3-[2-[[4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylamino]-2-oxoethyl]benzoic acid;N,N-diethylethanamine

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Reaction Conditions

Reaction Steps

To a solution of Example 56 (0.261 g) in a mixture of water (4 ml) and methanol (12 ml) was added a solution of sodium hydroxide (0.054 g) in water (0.5 ml) and the mixture was stirred at 20° C. for 72 h. The pH of the mixture was adjusted to approximately 6 by the addition of 2N hydrochloric acid and the mixture was purified by solid phase extraction (10 g SCX cartridge), eluting with methanol followed by 10% triethylamine in methanol. Evaporation of the basic fraction in vacuo gave the title compound as a colourless gum, (0.319 g).

Provenance & Evidence