Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | (2R,4R)-2-isobutyryloxymethyl-4-(2,6-diaminopurin-9-yl)-1,3-dioxolane | HCID 16050140 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | Amdoxovir | HCID 124088 | 83% |
Reaction Steps
31.05 g of (2R,4R)-2-isobutyryloxymethyl-4-(2,6-diaminopurin-9-yl)-1,3-dioxolane×2-propanol (cf. Example 4) were dissolved in 310 ml of NH3-saturated methanol. The solution was stirred at 25° C. for 15 h, and the solvent was distilled off in vacuo. The residue was recrystallized from ethanol/water. 17.10 g (83%) of (−)-DAPD were obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07560550B2 |
|---|
| Source dataset | uspto-grants-2009_07 |
|---|
| ORD ID | ord-b8b1fe9c93ec488987e4594a347b4e5b |
|---|
| Source note | uspto-grants-2009_07 |
|---|
