Benzyl isocyanate → HCID 67303715, compound

HRID 2274620Notes

Reaction equation

HRID 2274620 reaction equation
[NH2:1][CH2:2][C:3]([CH3:10])([CH3:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH2:11]([N:18]=[C:19]=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([NH:18][C:19](=[O:20])[NH:1][CH2:2][C:3]([CH3:10])([CH3:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 76639Benzyl isocyanateHCID 421529Ethyl 3-amino-2,2-dimethylpropanoate

Product 1

HCID 67303715HCID 67303715, compoundYield 60.4%

Procedure

According to the procedure described in the synthesis method of Compound V-3, ethyl 3-amino-2,2-dimethylpropanoate (2.90 mg, 20 mmol) was reacted with benzyl isocyanate (1.24 ml, 10 mmol) to obtain the title compound (1.68 g, 30%).

Sources & evidence

ORD record
ord-a66ed92463d846f3ab38bc708ebfeeac
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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